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AN ULTRAMICROSCOPIC STUDY OF THE TWO STAGES OF BLOOD COAGULATION

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Science  09 Jul 1920:
Vol. 52, Issue 1332, pp. 38-41
DOI: 10.1126/science.52.1332.38

Abstract

There is no reaction-basis for the division of the process of blood-coagulation into the two stages (transparent and opaque) which appearso strikingly in sloiwly-clotting mammalian blood. These stages are saperficial phenomena which merely reflect the extent of fibrin-formation. Coagulation is a gradual continuous process of fibrin-formation; and in the clotting of normal plasma, fibrin needles can be demonstrated in the earliest appreciable coagulum, however delicate, transparent or gellike.