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REVERSAL OF THE STIMULATING ACTION OF HYDROSTATIC PRESSURE ON STRIATED MUSCLE

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Science  03 Jan 1930:
Vol. 71, Issue 1827, pp. 17-18
DOI: 10.1126/science.71.1827.17

Abstract

The usual augmenting action of pressure on the tension developed by striated muscle in response to a single stimulus changes to depression on fatiguing the muscle. On release of the pressure the tension of the single twitch again reaches the control value.

A similar reversal may be brought about by cooling the muscle, the change usually occurring at about 13° C. Below this temperature the depression is roughly proportional to the pressure. At about 1° C. the tension development may be completely inhibited by high pressure. The muscle responds normally upon release of the pressure, and upon warming pressure again causes augmentation of contraction.