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Science  19 Jan 1940:
Vol. 91, Issue 2351, pp. 58-62
DOI: 10.1126/science.91.2351.58


During the decade following Dam's first observations on the hemorrhagic syndrome the combined efforts of several groups of investigators have solved many of the important problems connected with the new vitamin. Sources of vitamin K were discovered, methods of extraction and purification devised, the isolation effected, the structure of K1 worked out and then verified by synthesis, and a promising start made on the therapeutic applications. In addition, simple water soluble compounds with antihemorrhagic properties have been supplied for clinical work. Preliminary results with these compounds are encouraging.