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BIOTIN DEFICIENCY AND OTHER CHANGES IN RATS GIVEN SULFANILYLGUANIDINE OR SUCCINYL SULFATHIAZOLE IN PURIFIED DIETS

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Science  02 Oct 1942:
Vol. 96, Issue 2492, pp. 321-322
DOI: 10.1126/science.96.2492.321

Abstract

The following pathological changes have been observed in rats given sulfaguanidine or sulfasuxidine in purified diets.

1. A granulocytopenia, leukopenia, hypocellularity of bone marrow and, occasionally, an anemia.

2. Hyalinization, necrosis and calcification of voluntary muscle.

3. Hyaline sclerosis and calcification of blood vessels.

4. A dermatitis which can be prevented or successfully treated with crystalline biotin.

We have also observed necrosis of heart muscle, hemorrhage into various organs and subcutaneous tissues, and liver damage.