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PLASMA PROTHROMBIN CONCENTRATION IN DOGS GIVEN 3,3'-METHYLENEBIS(4- HYDROXYCOUMARIN) AND PURIFIED BEEF PROTHROMBIN

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Science  11 Dec 1942:
Vol. 96, Issue 2502, pp. 540
DOI: 10.1126/science.96.2502.540

Abstract

Purified beef prothrombin will antidote the hypoprothrombinemia induced in dogs by oral administration of 3,3'-methylenebis (4-hydroxyeoumarin). If the hypothesis is proven that this chemical compound acts only by preventing the production of prothrombin in the liver then the life of injected beef prothrombin is probably of the same duration as that of the dog's own plasma prothrombin; namely, 2 to 3 days.