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THE ROLE OF CALCIUM IN CARCINOGENESIS SUMMARY

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Science  24 Mar 1944:
Vol. 99, Issue 2569, pp. 245-247
DOI: 10.1126/science.99.2569.245-a

Abstract

Estimations of the calcium content of the mouse epidermis during the process of experimental carcinogenesis reveal two distinct phases: an immediate reduction in the calcium content which persists at a fairly constant level for many weeks and a further reduction when the epithelial cells have been transformed into cancer cells. Reduction of calcium in the hyperplastic epidermis is an important feature in this experimentally induced precancerous condition.

This investigation was aided by grants from the International Cancer Research Foundation and the National Cancer Institute.