Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

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Science  21 Oct 2010:
DOI: 10.1126/science.1194516


The intracerebral injection of β-amyloid–containing brain extracts can induce cerebral β-amyloidosis and associated pathologies in susceptible hosts. Here, we found that intraperitoneal inoculation with β-amyloid–rich extracts induced β-amyloidosis in the brains of β-amyloid precursor protein transgenic mice after prolonged incubation times.