The Cellular and Physiological Mechanism of Wing-Body Scaling in Manduca sexta

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Science  25 Nov 2010:
DOI: 10.1126/science.1197292


In animals, appendages develop in proportion to overall body size, and when individual size varies, appendages covary proportionally. In insects with complete metamorphosis, adult appendages develop from precursor tissues called imaginal disks that grow after somatic growth has ceased. It is unclear, however, how the growth of these appendages is matched to the already-established body size. We studied the pattern of cell division and found that both the rate of cell division and the duration of growth of the wing imaginal disks depend on the size of the body in which they develop, and that both of these processes are controlled by the level and duration of secretion of the steroid hormone ecdysone. Thus, proportional growth is under hormonal control and indirectly regulated by the central nervous system.