Technical Comments

Comment on “A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus”

Science  27 May 2011:

DOI: 10.1126/science.1201304

Abstract

Wolfe-Simon et al. (Science Express Research Article, published online 2 December 2010; 10.1126/science.1197258) reported that bacterium GFAJ-1 can substitute arsenic for phosphorus in its macromolecules, including DNA and proteins. If such arseno-DNA exists, then much of the past century of work with arsenate and phosphate chemistry, as well as much of what we think we know about metabolism, will need rewriting.