Editorial Expression of Concern

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Science  31 May 2011:
DOI: 10.1126/science.1208542


In the issue of 23 October 2009, Science published a study by Lombardi et al. purporting to show that a retrovirus called XMRV (xenotropic murine leukemia virus-related virus) was present in the blood of 67% of patients with chronic fatigue syndrome (CFS) compared with 3.7% of healthy controls. A number of studies published elsewhere have failed to replicate these findings. In conjunction with two new Reports that strongly support the growing view that the association between XMRV and CFS likely reflects contamination of laboratories and research reagents with the virus, Science is publishing an Editorial Expression of Concern about the Lombardi et al. Report.