Editorial Expression of Concern

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Science  03 Oct 2011:
DOI: 10.1126/science.1214735


In the 4 June 2010 issue, Science published the Report “SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis” by P. Puneet et al. [Science 328, 1290 (2010)]. On 22 March 2011, Science learned that authorities at the authors' principal institutions at the time of publication and the corresponding author's more recent affiliation were investigating allegations of figure manipulation in the Science Report. The investigation has not yet reached a conclusion. Pending the results of the investigations, Science is publishing this Editorial Expression of Concern to alert our readers to the fact that serious questions have been raised about the validity of findings in the Puneet et al. paper.