Report

Unique Processing During a Period of High Excitation/Inhibition Balance in Adult-Born Neurons

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Science  26 Jan 2012:
1214956
DOI: 10.1126/science.1214956

Abstract

The adult dentate gyrus generates new granule cells (GCs) that develop over several weeks and integrate into the preexisting network. While adult hippocampal neurogenesis has been implicated in learning and memory, the specific role of new GCs remains unclear. We examined whether immature adult-born neurons contribute to information encoding. Combining calcium imaging and electrophysiology in acute slices, we found that weak afferent activity recruits few mature GCs while activating a substantial proportion of the immature neurons. These different activation thresholds are dictated by an enhanced excitation/inhibition balance transiently expressed in immature GCs. Immature GCs exhibit low input specificity that switches with time towards a highly specific responsiveness. Therefore, activity patterns entering the dentate gyrus can undergo differential decoding by a heterogeneous population of GCs originated at different times.