Identification of Wheat Gene Sr35 That Confers Resistance to Ug99 Stem Rust Race Group

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Science  27 Jun 2013:
DOI: 10.1126/science.1239022

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Wheat stem rust, caused by Puccinia graminis f. sp. tritici (Pgt), is a devastating disease that can cause severe yield losses. A new Pgt race designated Ug99 has overcome most of the widely used resistance genes and is threatening major wheat production areas. Here, we demonstrate that the Sr35 gene from Triticum monococcum is a coiled coil-nucleotide binding-leucine rich repeat gene that confers near-immunity to Ug99 and related races. This gene is absent in the A-genome diploid donor and in polyploid wheat, but is effective when transferred from T. monococcum to polyploid wheat. The cloning of Sr35 opens the door to the use of biotechnological approaches to control this devastating disease and to the analyses of the molecular interactions that define the wheat-rust pathosystem.

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