Report

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

+ See all authors and affiliations

Science  08 Aug 2013:
1240933
DOI: 10.1126/science.1240933

You are currently viewing the abstract.

View Full Text

Abstract

Retroviruses, including HIV, can activate innate immune responses, but the host sensors for retroviruses are largely unknown. Here, we show that HIV infection activates cyclic-GMP–AMP (cGAMP) synthase (cGAS) to produce cGAMP, which binds to and activates the adaptor protein STING to induce type-I interferons and other cytokines. Inhibitors of HIV reverse transcriptase, but not integrase, abrogated interferon-β induction by the virus, suggesting that the reverse transcribed HIV DNA triggers the innate immune response. Knockout or knockdown of cGAS in mouse or human cell lines blocked cytokine induction by HIV, murine leukemia virus (MLV), and simian immunodeficiency virus (SIV). These results indicate that cGAS is an innate immune sensor of HIV and other retroviruses.

View Full Text