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Coordinated Effects of Sequence Variation on DNA Binding, Chromatin Structure, and Transcription

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Science  17 Oct 2013:
1242463
DOI: 10.1126/science.1242463

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  • Received for publication June 26, 2013
  • Accepted for publication September 12, 2013

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  1. Helena Kilpinen1,2,3,*,
  2. Sebastian M. Waszak2,4,*,
  3. Andreas R. Gschwind2,5,*,
  4. Sunil K. Raghav4,
  5. Robert M. Witwicki5,
  6. Andrea Orioli5,
  7. Eugenia Migliavacca2,5,
  8. Michaël Wiederkehr5,
  9. Maria Gutierrez-Arcelus1,2,3,
  10. Nikolaos Panousis1,2,3,
  11. Alisa Yurovsky1,2,3,
  12. Tuuli Lappalainen1,2,3,
  13. Luciana Romano-Palumbo1,
  14. Alexandra Planchon1,
  15. Deborah Bielser1,
  16. Julien Bryois1,2,3,
  17. Ismael Padioleau1,2,3,
  18. Gilles Udin4,
  19. Sarah Thurnheer6,
  20. David Hacker6,
  21. Leighton J. Core7,
  22. John T. Lis7,
  23. Nouria Hernandez5,,
  24. Alexandre Reymond5,,
  25. Bart Deplancke2,4,,
  26. Emmanouil T. Dermitzakis1,2,3,8,
  1. 1Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
  2. 2Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
  3. 3Institute of Genetics and Genomics of Geneva, University of Geneva, 1211 Geneva, Switzerland.
  4. 4Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
  5. 5Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
  6. 6Protein Expression Core Facility, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
  7. 7Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
  8. 8Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  1. Corresponding author. E-mail: emmanouil.dermitzakis{at}unige.ch (E.T.D.); bart.deplancke{at}epfl.ch (B.D.); alexandre.reymond{at}unil.ch (A.R.); nouria.hernandez{at}unil.ch (N.H.)
  1. * These authors contributed equally to this work.

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