Merging photoredox with nickel catalysis: Coupling of α-carboxyl sp3-carbons with aryl halides

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Science  05 Jun 2014:
DOI: 10.1126/science.1255525

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Over the last 40 years, transition metal catalysis has enabled bond formation between aryl and olefinic (sp2) carbons in a selective and predictable manner with high functional group tolerance. Couplings involving alkyl (sp3) carbons have proven more challenging. Here, we demonstrate that the synergistic combination of photoredox catalysis and nickel catalysis provides an alternative cross-coupling paradigm, in which simple and readily available organic molecules can be systematically employed as coupling partners. Using this photoredox-metal catalysis approach, we have achieved a direct decarboxylative sp3–sp2 cross coupling of amino acids, as well as α-O- or phenyl-substituted carboxylic acids, with aryl halides. Moreover, this mode of catalysis can be applied to direct cross-coupling of Embedded Image–H in dimethylaniline with aryl halides via C–H functionalization.

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