Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert

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Science  28 Aug 2014:
DOI: 10.1126/science.1254803

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After an infection, pathogen-specific tissue-resident memory T cells (Trm) persist in nonlymphoid tissues to provide rapid control upon reinfection, and vaccination strategies that create Trm pools at sites of pathogen entry are therefore attractive. However, it is not well understood how Trm provide such pathogen protection. Here, we demonstrate that activated Trm in mouse skin profoundly alter the local tissue environment by inducing a number of broadly active antiviral and antibacterial genes. This “pathogen alert” allows skin Trm to protect against an antigenically unrelated virus. These data describe a mechanism by which tissue-resident memory CD8+ T cells protect previously infected sites that is rapid, amplifies the activation of a small number of cells into an organ-wide response, and has the capacity to control escape variants.

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