Genomic structure in Europeans dating back at least 36,200 years

Andaine Seguin-Orlando; Thorfinn S. Korneliussen; Martin Sikora; Anna-Sapfo Malaspinas; Andrea Manica; Ida Moltke; Anders Albrechtsen; Amy Ko; Ashot Margaryan; Vyacheslav Moiseyev; Ted Goebel; Michael Westaway; David Lambert; Valeri Khartanovich; Jeffrey D. Wall; Philip R. Nigst; Robert A. Foley; Marta Mirazon Lahr; Rasmus Nielsen; Ludovic Orlando; Eske Willerslev

doi:10.1126/science.aaa0114

Report

Genomic structure in Europeans dating back at least 36,200 years

Andaine Seguin-Orlando¹,*,
Thorfinn S. Korneliussen¹,*,
Martin Sikora¹,*,
Anna-Sapfo Malaspinas¹,
Andrea Manica²,
Ida Moltke³,⁴,
Anders Albrechtsen⁴,
Amy Ko⁵,
Ashot Margaryan¹,
Vyacheslav Moiseyev⁶,
Ted Goebel⁷,
Michael Westaway⁸,
David Lambert⁸,
Valeri Khartanovich⁶,
Jeffrey D. Wall⁹,
Philip R. Nigst¹⁰,¹¹,
Robert A. Foley¹,¹²,
Marta Mirazon Lahr¹,¹²,^†,
Rasmus Nielsen⁵,^†,
Ludovic Orlando¹,
Eske Willerslev¹,^†

¹Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, Denmark.
²Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK.
³Department of Human Genetics, University of Chicago, 920 East 58th Street, CLSC, Chicago, IL 60637, USA.
⁴The Bioinformatics Center, University of Copenhagen, Ole Maaløes Vej 5, 2200 København N, Denmark.
⁵Department of Integrative Biology, University of California, Berkeley, CA 94720, USA.
⁶Department of Physical Anthropology, Kunstkamera, Peter the Great Museum of Anthropology and Ethnography, Russian Academy of Sciences, 24 Srednii Prospect, Vassilievskii Island, St. Peterburg, Russia.
⁷Center for the Study of the First Americans and Department of Anthropology, Texas A&M University, TAMU-4352, College Station, Texas 77845-4352, USA.
⁸Griffith University, Nathan Campus, 170 Kessels Road, Nathan, Brisbane, Queensland 4111, Australia.
⁹Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, Lobby 5, Suite 5700, San Francisco, CA 94107, USA.
¹⁰Division of Archaeology, University of Cambridge, Cambridge, Downing Street, CB2 3DZ, UK.
¹¹Department of Human Evolution, Max-Planck-Institute for Evolutionary Anthropology, Leipzig, Deutscher Platz 6, D-04103, Germany.
¹²Leverhulme Centre for Human Evolutionary Studies, Department of Archaeology and Anthropology, University of Cambridge, Cambridge, Fitzwilliam Street, CB2 1QH, UK.

↵†Corresponding author. E-mail: ewillerslev{at}snm.ku.dk (E.W.), rasmus_nielsen{at}berkeley.edu (R.N.), mbml1{at}cam.ac.uk (M.M.L.)

↵* These authors contributed equally to the work.

See allHide authors and affiliations

Science 06 Nov 2014:
aaa0114
DOI: 10.1126/science.aaa0114

Andaine Seguin-Orlando

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Thorfinn S. Korneliussen

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Martin Sikora

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Anna-Sapfo Malaspinas

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andrea Manica

Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ida Moltke

Department of Human Genetics, University of Chicago, 920 East 58th Street, CLSC, Chicago, IL 60637, USA.The Bioinformatics Center, University of Copenhagen, Ole Maaløes Vej 5, 2200 København N, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Anders Albrechtsen

The Bioinformatics Center, University of Copenhagen, Ole Maaløes Vej 5, 2200 København N, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Amy Ko

Department of Integrative Biology, University of California, Berkeley, CA 94720, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ashot Margaryan

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Vyacheslav Moiseyev

Department of Physical Anthropology, Kunstkamera, Peter the Great Museum of Anthropology and Ethnography, Russian Academy of Sciences, 24 Srednii Prospect, Vassilievskii Island, St. Peterburg, Russia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ted Goebel

Center for the Study of the First Americans and Department of Anthropology, Texas A&M University, TAMU-4352, College Station, Texas 77845-4352, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Michael Westaway

Griffith University, Nathan Campus, 170 Kessels Road, Nathan, Brisbane, Queensland 4111, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

David Lambert

Griffith University, Nathan Campus, 170 Kessels Road, Nathan, Brisbane, Queensland 4111, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Valeri Khartanovich

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jeffrey D. Wall

Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, Lobby 5, Suite 5700, San Francisco, CA 94107, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Philip R. Nigst

Division of Archaeology, University of Cambridge, Cambridge, Downing Street, CB2 3DZ, UK.Department of Human Evolution, Max-Planck-Institute for Evolutionary Anthropology, Leipzig, Deutscher Platz 6, D-04103, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Robert A. Foley

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, Denmark.Leverhulme Centre for Human Evolutionary Studies, Department of Archaeology and Anthropology, University of Cambridge, Cambridge, Fitzwilliam Street, CB2 1QH, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Marta Mirazon Lahr

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: ewillerslev@snm.ku.dkrasmus_nielsen@berkeley.edumbml1@cam.ac.uk

Rasmus Nielsen

Department of Integrative Biology, University of California, Berkeley, CA 94720, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: ewillerslev@snm.ku.dkrasmus_nielsen@berkeley.edumbml1@cam.ac.uk

Ludovic Orlando

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Eske Willerslev

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, Denmark.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: ewillerslev@snm.ku.dkrasmus_nielsen@berkeley.edumbml1@cam.ac.uk

Article
Figures & Data
Info & Metrics
eLetters
PDF

Log in to view full text

via AAAS login

AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.

Become a AAAS member
Activate account
Add journals
Account help

As a service to the community, this article is available for free. Existing users log in.

Become a AAAS member
Account help

Log in through your institution

More options

Purchase digital access to this article

Download and print this article for your personal scholarly, research, and educational use.

Purchase this issue in print

Buy a single issue of Science for just $15 USD.

Genomic structure in Europeans dating back at least 36,200 years

Log in to view full text

Log in through your institution

Log in through your institution

More options

Article Tools