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Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

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Science  08 Oct 2015:
aac5789
DOI: 10.1126/science.aac5789

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History: 
  • Received for publication May 14, 2015
  • Accepted for publication September 14, 2015

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  1. Liman Zhang1,2,*,
  2. Shuobing Chen3,4,*,
  3. Jianbin Ruan1,2,
  4. Jiayi Wu3,4,
  5. Alexander B. Tong1,2,
  6. Qian Yin1,2,
  7. Yang Li1,2,
  8. Liron David1,2,
  9. Alvin Lu1,2,
  10. Wei Li Wang4,5,
  11. Carolyn Marks6,
  12. Qi Ouyang3,
  13. Xinzheng Zhang7,
  14. Youdong Mao3,4,5,,
  15. Hao Wu1,2,
  1. 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115, USA.
  3. 3Center for Quantitative Biology, Peking-Tsinghua Joint Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China.
  4. 4Department of Cancer Immunology and Virology, Intel Parallel Computing Center for Structural Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  5. 5Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
  6. 6Center for Nanoscale Systems, Harvard University, Cambridge, MA 02138, USA.
  7. 7National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  1. Corresponding author. E-mail: wu{at}crystal.harvard.edu (H.W.); youdong_mao{at}dfci.harvard.edu (Y.M.)
  1. * These authors contributed equally to this work.

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