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Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor

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Science  07 Jul 2016:
aag2419
DOI: 10.1126/science.aag2419

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History: 
  • Received for publication May 28, 2016
  • Accepted for publication June 30, 2016

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Author Information

  1. Jian Lei1,2,
  2. Guido Hansen1,
  3. Christoph Nitsche3,*,
  4. Christian D. Klein3,
  5. Linlin Zhang1,2,
  6. Rolf Hilgenfeld1,2,
  1. 1Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.
  2. 2German Center for Infection Research (DZIF), Hamburg–Lübeck–Borstel–Riems Site, University of Lübeck, Germany.
  3. 3Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.
  1. Corresponding author. Email: hilgenfeld{at}biochem.uni-luebeck.de
  • * Present address: Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.

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Aug 201619877551080
Sep 20161158425547
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