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Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

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Science  09 Mar 2017:
eaaf0683
DOI: 10.1126/science.aaf0683

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PubMed: 
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History: 
  • Received for publication 21 December 2015.
  • Resubmitted 9 November 2016.
  • Accepted for publication 6 January 2017.

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Author Information

  1. Alice O. Kamphorst1,
  2. Andreas Wieland1,
  3. Tahseen Nasti1,
  4. Shu Yang1,2,
  5. Ruan Zhang3,
  6. Daniel L. Barber1,4,
  7. Bogumila T. Konieczny1,
  8. Candace Z. Daugherty1,
  9. Lydia Koenig5,
  10. Ke Yu5,
  11. Gabriel L. Sica6,
  12. Arlene H. Sharpe7,
  13. Gordon J. Freeman8,
  14. Bruce R. Blazar9,
  15. Laurence A. Turka3,
  16. Taofeek K. Owonikoko5,
  17. Rathi Pillai5,
  18. Suresh S. Ramalingam5,
  19. Koichi Araki1,
  20. Rafi Ahmed1,*
  1. 1Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta-GA, 30322 USA.
  2. 2Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China, 410013. Present address: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052 China.
  3. 3Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02144, USA.
  4. 4Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
  5. 5Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.
  6. 6Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.
  7. 7Department of Microbiology and Immunobiology and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Woman’s Hospital, Boston, MA 02115, USA.
  8. 8Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  9. 9Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA.
  1. *Corresponding author. Email: rahmed{at}emory.edu

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