ReportCRISPR TECHNOLOGY

Nucleic acid detection with CRISPR-Cas13a/C2c2

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Science  13 Apr 2017:
eaam9321
DOI: 10.1126/science.aam9321

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History: 
  • Received for publication February 6, 2017
  • Accepted for publication April 5, 2017

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  1. Jonathan S. Gootenberg1,2,3,4,5,*,
  2. Omar O. Abudayyeh1,2,3,4,6,*,
  3. Jeong Wook Lee7,
  4. Patrick Essletzbichler1,2,3,4,
  5. Aaron J. Dy1,4,8,
  6. Julia Joung1,2,3,4,
  7. Vanessa Verdine1,2,3,4,
  8. Nina Donghia7,
  9. Nichole M. Daringer8,
  10. Catherine A. Freije1,11,
  11. Cameron Myhrvold1,11,
  12. Roby P. Bhattacharyya1,
  13. Jonathan Livny1,
  14. Aviv Regev1,9,
  15. Eugene V. Koonin10,
  16. Deborah T. Hung1,
  17. Pardis C. Sabeti1,11,12,13,
  18. James J. Collins1,4,6,7,8,,
  19. Feng Zhang1,2,3,4,
  1. 1Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  2. 2McGovern Institute for Brain Research at MIT, Cambridge, MA 02139, USA.
  3. 3Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  4. 4Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  5. 5Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  6. 6Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  7. 7Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
  8. 8Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  9. 9Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  10. 10National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
  11. 11Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  12. 12Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA.
  13. 13Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  1. Corresponding author. Email: zhang{at}broadinstitute.org(F.Z); jimjc{at}mit.edu(J.J.C.)
  1. * These authors contributed equally to this work.

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