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Abstract
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BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis
Luca Scorrano, Scott A. Oakes, Joseph T. Opferman, Emily H. Cheng, Mia D. Sorcinelli, Tullio Pozzan, Stanley J. Korsmeyer

Supporting Online Material

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Materials and Methods
Figs. S1 to S7

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  • Movie S1
    Real time imaging of mitochondrial Ca2+ uptake in wt (left) and DKO (right) MEFs. Rhod2 fluorescence was imaged every 500 msec. The frame corresponding to Thapsigargin addition is kept still for 1 sec.
  • Movie S2
    Real time mitochondrial membrane potential imaging in wt (left) and DKO (right) MEFs. An entire sequence of TMRM fluorescence is shown. The frame corresponding to the addition of arachidonic acid (ArA) is kept still for 1 sec. See Supp. Fig. 6 legend for more details.
  • Movie S3
    Real time mitochondrial membrane potential imaging in wt (left) and DKO (right) MEFs. An entire sequence of TMRM fluorescence is shown. The frames corresponding to the addition of histamine (Hist) and arachidonic acid (ArA) are kept still for 1 sec. See Supp. Fig. 6 legend for more details.
  • Movie S4
    Real time mitochondrial membrane potential imaging in wt (left) and DKO (right) MEFs. An entire sequence of TMRM fluorescence is shown. The frames corresponding to the addition of ionomycin (Iono) and arachidonic acid (ArA) are kept still for 1 sec. See Supp. Fig. 6 legend for more details.