Online Enhancements


Abstract
Full Text
Functional Genomic Analysis of the Wnt-Wingless Signaling Pathway
Ramanuj DasGupta, Ajamete Kaykas, Randall T. Moon, and Norbert Perrimon

Online Enhancements

This Research Article by DasGupta et al. is enhanced by links to the Connections Maps database at Science's Signal Transduction Knowledge Environment (STKE). This database of information on signal transduction pathways is available free and without subscription (only registration is required). Leading authorities provide the information on signaling components and their relations that is stored in the Connections Maps database. It provides users with a way to view the biochemical pathways that regulate biological processes and a simple graphical interface to explore the molecules that make up these pathways and how they interact with one another.

This Research Article discusses many of the molecules that participate in the Wnt signaling pathway. The first time these molecules are mentioned in the text, they are linked to appropriate records in the Connections Maps database. From these pages, readers can explore the signaling pathway further and obtain additional background information that may be useful in understanding the paper by DasGupta et al. The database contains "canonical" or generalized pathways (the canonical Wnt/beta-catenin pathway and a Wnt-Ca2+/cAMP pathway), as well as "specific" pathways that represent pathways established in a particular species and cell type (four specific Wnt pathways in C. elegans, one for Drosophila, and one for Xenopus). Information on individual components is available in "pathway-independent" component records (providing general information about a molecule) or in "pathway-dependent" component records (which provide information on the molecules function in the context of a particular pathway).

We welcome your comments on this enhanced presentation of research in Science or on the Connections Maps database. Please send them to http://stke.sciencemag.org/cgi/feedback.