RT Journal Article SR Electronic T1 Transcriptional Regulation of Cortical Neuron Migration by POU Domain Factors JF Science JO Science FD American Association for the Advancement of Science SP 1528 OP 1532 DO 10.1126/science.1067132 VO 295 IS 5559 A1 McEvilly, Robert J. A1 de Diaz, Marcela Ortiz A1 Schonemann, Marcus D. A1 Hooshmand, Farideh A1 Rosenfeld, Michael G. YR 2002 UL http://science.sciencemag.org/content/295/5559/1528.abstract AB The identification of pathways mediated by the kinase Cdk5 and the ligand reelin has provided a conceptual framework for exploring the molecular mechanisms underlying proper lamination of the developing mammalian cerebral cortex. In this report, we identify a component of the regulation of Cdk5-mediated cortical lamination by genetic analysis of the roles of the class III POU domain transcription factors, Brn-1 and Brn-2, expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons. Brn-1 and Brn-2 appear to critically control the initiation of radial migration, redundantly regulating the cell-autonomous expression of the p35 and p39 regulatory subunits of Cdk5 in migrating cortical neurons, withBrn-1(−/−)/Brn-2(−/−) mice exhibiting cortical inversion.