PT  - JOURNAL ARTICLE
AU  - Zhong, Weiwei
AU  - Sternberg, Paul W.
TI  - Genome-Wide Prediction of <em>C. elegans</em> Genetic Interactions
AID  - 10.1126/science.1123287
DP  - 2006 Mar 10
TA  - Science
PG  - 1481--1484
VI  - 311
IP  - 5766
4099  - http://science.sciencemag.org/content/311/5766/1481.short
4100  - http://science.sciencemag.org/content/311/5766/1481.full
SO  - Science2006 Mar 10; 311
AB  - To obtain a global view of functional interactions among genes in a metazoan genome, we computationally integrated interactome data, gene expression data, phenotype data, and functional annotation data from three model organisms—Saccharomyces cerevisiae, Caenorhabditis elegans, and Drosophila melanogaster—and predicted genome-wide genetic interactions in C. elegans. The resulting genetic interaction network (consisting of 18,183 interactions) provides a framework for system-level understanding of gene functions. We experimentally tested the predicted interactions for two human disease-related genes and identified 14 new modifiers.