PT  - JOURNAL ARTICLE
AU  - Takken, F. L. W.
AU  - Tameling, W. I. L.
TI  - To Nibble at Plant Resistance Proteins
AID  - 10.1126/science.1171666
DP  - 2009 May 08
TA  - Science
PG  - 744--746
VI  - 324
IP  - 5928
4099  - http://science.sciencemag.org/content/324/5928/744.short
4100  - http://science.sciencemag.org/content/324/5928/744.full
SO  - Science2009 May 08; 324
AB  - To intercept invading microbes that threaten growth and reproduction, plants evolved a sophisticated innate immune system. Recognition of specialized pathogens is mediated by resistance proteins that function as molecular switches. Pathogen perception by these multidomain proteins seems to trigger a series of conformational changes dependent on nucleotide exchange. The activated resistance protein switches on host defenses, often culminating in the death of infected cells. Given their control over life and death, activity of these proteins requires tight regulation that involves intramolecular interactions between the various domains.