RT Journal Article
SR Electronic
T1 Correlated gene expression supports synchronous activity in brain networks
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1241
OP 1244
DO 10.1126/science.1255905
VO 348
IS 6240
A1 Richiardi, Jonas
A1 Altmann, Andre
A1 Milazzo, Anna-Clare
A1 Chang, Catie
A1 Chakravarty, M. Mallar
A1 Banaschewski, Tobias
A1 Barker, Gareth J.
A1 Bokde, Arun L.W.
A1 Bromberg, Uli
A1 Büchel, Christian
A1 Conrod, Patricia
A1 Fauth-Bühler, Mira
A1 Flor, Herta
A1 Frouin, Vincent
A1 Gallinat, Jürgen
A1 Garavan, Hugh
A1 Gowland, Penny
A1 Heinz, Andreas
A1 Lemaître, Hervé
A1 Mann, Karl F.
A1 Martinot, Jean-Luc
A1 Nees, Frauke
A1 Paus, Tomáš
A1 Pausova, Zdenka
A1 Rietschel, Marcella
A1 Robbins, Trevor W.
A1 Smolka, Michael N.
A1 Spanagel, Rainer
A1 Ströhle, Andreas
A1 Schumann, Gunter
A1 Hawrylycz, Mike
A1 Poline, Jean-Baptiste
A1 Greicius, Michael D.
A1 ,
YR 2015
UL http://science.sciencemag.org/content/348/6240/1241.abstract
AB When the brain is at rest, a number of distinct areas are functionally connected. They tend to be organized in networks. Richiardi et al. compared brain imaging and gene expression data to build computational models of these networks. These functional networks are underpinned by the correlated expression of a core set of 161 genes. In this set, genes coding for ion channels and other synaptic functions such as neurotransmitter release dominate.Science, this issue p. 1241During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.