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Your search for author "Chris Tyler-Smith" returned 11 results.

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  • Ancient human parallel lineages within North America contributed to a coastal expansion

    Two parallel, terminal Pleistocene lineages gave rise to Californian, Central, and South American populations.

  • Paleolithic networking

    Genomes reveal patterns of genetic and social interactions in Neandertal and Paleolithic hunter-gatherer groups

  • A Neolithic expansion, but strong genetic structure, in the independent history of New Guinea

    The population structure in Papua New Guinea reflects a Neolithic transition with high present-day genetic differentiation.

  • Chimpanzee genomic diversity reveals ancient admixture with bonobos

    Genome sequences reveal ancient interbreeding between chimpanzees and bonobos.

  • Health and population effects of rare gene knockouts in adult humans with related parents

    The total loss of protein-coding genes, even those with the potential to confer genetic diseases, can be tolerated.

  • Global diversity, population stratification, and selection of human copy-number variation

    Copy-number variation reveals how selection affects the human genome across the globe.

  • Genomic evidence for the Pleistocene and recent population history of Native Americans

    Genetic variation within ancient and extant Native American populations informs on their migration into the Americas.

  • Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding

    Inbreeding in mountain gorillas increases the threat from disease and environmental change but has purged deleterious mutations.

  • Integrative Annotation of Variants from 1092 Humans: Application to Cancer Genomics

    Regions under strong selection in the human genome identify noncoding regulatory elements with possible roles in disease.

  • A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes

    Validation of predicted nonfunctional alleles in the human genome affects the medical interpretation of genomic analyses.

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