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Your search for author "George D. Yancopoulos" returned 11 results.

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  • Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype

    Synergistic CD8+ T cell activation by antibodies to PD-1 and GITR in cancer immunotherapy depends on the CD226 costimulatory pathway.

  • Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study

    More than 50,000 exomes, coupled with electronic health records, inform on medically relevant genetic variants.

  • Genetic identification of familial hypercholesterolemia within a single U.S. health care system

    Genomic screening can prompt the diagnosis of familial hypercholesterolemia patients, the majority of whom are receiving inadequate lipid-lowering therapy.

  • ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

    In patients with fibrodysplasia ossificans progressiva, the disease-causing mutation changes the ligand response profile of the ACVR1 receptor so that it is activated by the normally antagonistic ligand activin A.

  • Ric-8 Proteins Are Molecular Chaperones That Direct Nascent G Protein α Subunit Membrane Association

    Control of the insertion of G protein α subunits into endomembranes by Ric-8 proteins regulates the abundance and function of heterotrimeric G proteins.

  • Regulation of the Germinal Center Response by MicroRNA-155

    Deletion of a microRNA sequence in mice impairs their immunity, causing abnormal immune responses and cytokine production, as well as gut and lung inflammation.

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