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Your search for author "Nickolas Papadopoulos" returned 25 results.

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  • Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

    Endometrial and ovarian cancers can be detected through the analysis of DNA from Pap test fluids, intrauterine samples, and plasma.

  • Detection and localization of surgically resectable cancers with a multi-analyte blood test

    A blood test that combines protein and DNA markers may allow earlier detection of eight common cancer types.

  • Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

    A pan-cancer biomarker is identified that can predict successful response to cancer immunotherapy in human patients.

  • Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

    Detection of circulating tumor DNA in patients with resected stage II colon cancer provides evidence of residual disease.

  • Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

    Cancer cells with certain mutations take up the oxidized form of vitamin C, which fatally disrupts their metabolism. [Also see Perspective by Reczek and Chandel]

  • Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas

    Tumor DNA in saliva and plasma can provide a noninvasive biomarker for head and neck squamous cell carcinoma.

  • Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses

    Clostridium novyi-NT targets aberrant tumor physiology and can produce a precise, robust, and reproducible antitumor response.

  • Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

    Circulating tumor DNA can be used in a variety of clinical and investigational settings across tumor types and stages for screening, diagnosis, and identifying mutations responsible for therapeutic response and drug resistance.

  • Association of the Autoimmune Disease Scleroderma with an Immunologic Response to Cancer

    The immune system’s response to a mutant protein produced by an incipient cancer may help to explain an autoimmune disease. [Also see Perspective by Teng and Smyth]

  • Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

    The mutational signature of aristolochic acid exemplifies how genome-wide sequencing can be used to identify environmental exposures leading to cancer.

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