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Your search for author "Richard A. Gibbs" returned 21 results.

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  • The comparative genomics and complex population history of Papio baboons

    We analyzed genome sequences from 6 baboon species and found evidence of ancient and recent hybridization among divergent species.

  • The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders

    POU3F2 regulates expression of key genes in postmortem brain tissue from patients with schizophrenia or bipolar disorder.

  • The sheep genome illuminates biology of the rumen and lipid metabolism

    A genomic analysis of sheep explains specializations in digestive system physiology and wool production.

  • Integrative Annotation of Variants from 1092 Humans: Application to Cancer Genomics

    Regions under strong selection in the human genome identify noncoding regulatory elements with possible roles in disease.

  • Landscape of Somatic Retrotransposition in Human Cancers

    Whole-genome sequencing provides evidence for somatic insertions in colorectal, prostate, and ovarian cancers.

  • A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes

    Validation of predicted nonfunctional alleles in the human genome affects the medical interpretation of genomic analyses.

  • Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

    The mutational profile of head and neck cancer is complex and may pose challenges to the development of targeted therapies.

  • Whole-Genome Sequencing for Optimized Patient Management

    A disease mutation identified by whole-genome sequencing of twins with dystonia allowed optimization of treatment, resulting in clinical improvements.

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