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Your search for author "Zhiyong Yang" returned 14 results.

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  • An autoimmune disease variant of IgG1 modulates B cell activation and differentiation

    A variant of IgG1 modulates B cell responses and autoimmunity.

  • Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

    Engineered trispecific antibodies interact with three independent HIV-1 envelope determinants and prevent infection.

  • Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

    Neutralizing antibodies to HIV-1 envelope protect more effectively than an antibody to the CD4 cell receptor in rhesus macaques.

  • Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination

    A V1-V2 IgG3 response to HIV correlates with a decreased risk of HIV-1 infection and is one vaccine-induced humoral response that is higher in a clinical trial showing HIV-1 vaccine efficacy compared to a trial showing nonefficacy.

  • Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

    Broadly neutralizing antibodies to HIV with similar specificities can be found in multiple HIV-infected individuals.

  • Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

    A human antibody achieves broad neutralization by binding the viral site of recognition for the primary host receptor, CD4.

  • Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

    A human antibody achieves broad neutralization by binding the viral site of recognition for the primary host receptor, CD4.

  • Cross-Neutralization of 1918 and 2009 Influenza Viruses: Role of Glycans in Viral Evolution and Vaccine Design

    The 1918 and 2009 pandemic influenza viruses are both inhibited by antibodies directed to an exposed region of the viral spike, but this region becomes shielded by glycans in influenza seasonal strains.

  • Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

    Conformational variability in an HIV coat protein complicates the therapeutic targeting of HIV-1.

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