Genetics

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

By Erwei Zuo, Yidi Sun, Wu Wei, Tanglong Yuan, Wenqin Ying, Hao Sun, Liyun Yuan, Lars M. Steinmetz, Yixue Li, Hui Yang

Science18 Apr 2019 : 289-292 You have accessRestricted access

Cytosine base editing in mouse embryos generates numerous off-target single-nucleotide variants.
Tissue specificity of tumor suppression

By L. Bryan Ray

Science18 Apr 2019 : 249 You have accessRestricted access
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When genome editing goes off-target

By Hannah R. Kempton, Lei S. Qi

Science18 Apr 2019 : 234-236 You have accessRestricted access

Detecting unintended mutations could improve DNA-editing strategies
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Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice

By Shuai Jin, Yuan Zong, Qiang Gao, Zixu Zhu, Yanpeng Wang, Peng Qin, Chengzhi Liang, Daowen Wang, Jin-Long Qiu, Feng Zhang, Caixia Gao

Science18 Apr 2019 : 292-295 You have accessRestricted access

Whole-genome sequencing analyses reveal substantial off-target mutations induced by cytosine base editors in rice.
Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1

By Meng He, Mira S. Chaurushiya, Joshua D. Webster, Sarah Kummerfeld, Rohit Reja, Subhra Chaudhuri, Ying-Jiun Chen, Zora Modrusan, Benjamin Haley, Debra L. Dugger, Jeffrey Eastham-Anderson, Shari Lau, Anwesha Dey, Roger Caothien, Merone Roose-Girma, Kim Newton, Vishva M. Dixit

Science18 Apr 2019 : 283-285 You have accessRestricted access

Why does tumor-suppressor BAP1 lead to cancer only in specific tissues?
Spotting off-targets from gene editing

By Steve Mao

Science18 Apr 2019 : 249 You have accessRestricted access
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Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution

By Samuel G. Rodriques, Robert R. Stickels, Aleksandrina Goeva, Carly A. Martin, Evan Murray, Charles R. Vanderburg, Joshua Welch, Linlin M. Chen, Fei Chen, Evan Z. Macosko

Science28 Mar 2019 : 1463-1467 You have accessRestricted access

An RNA sequencing technique is developed that can measure genome-wide gene expression in complex tissues at 10-micrometer resolution.
Gene expression at fine scale

By Laura M. Zahn

Science28 Mar 2019 : 1411-1412 You have accessRestricted access
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Locating myxomatosis resistance

By Caroline Ash

Science21 Mar 2019 : 1296 You have accessRestricted access
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Sequencing and the single sperm

By Laura M. Zahn

Science21 Mar 2019 : 1296-1298 You have accessRestricted access
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