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Genetics
- Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
Lee et al. bolster a tumor suppressor as a potential cancer therapy.
- Genomics breeds new legal questions
Experts try to bring laws, regulations in line with genetic testing as its use surges.
- Vision using multiple distinct rod opsins in deep-sea fishes
Rod opsin proliferation in deep-sea fish allows for light limited color vision.
- LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling
A receptor unknown to be involved in immunity regulates lymphocyte development in mice.
- Chromatin three-dimensional interactions mediate genetic effects on gene expression
Linking genetic variants, gene expression, and chromatin organization elucidates the genomic architecture of human quantitative traits.
- Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response
Effective PD-1 immunotherapy is influenced by the intensity of tumor microsatellite instability.