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Immunology

  • Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade

    Image analysis methods from astronomy improve tumor characterization and prediction of immunotherapy response.

  • Senolytics reduce coronavirus-related mortality in old mice

    DOI: 10.1126/science.abe4832

  • Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

    DOI: 10.1126/science.abf9277

  • Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

    DOI: 10.1126/science.abf7844

  • Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling

    The highly conserved nature of T cell antigen receptor recognition is required for the colocalization of key signaling molecules.

  • Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

    Plasma immunoglobulin G responses to the SARS-CoV-2 spike contain shared, or “public,” antibodies against a site that is recurrently mutated in variants of concern.

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