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Physiology

  • Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

    Deletion of dihydroceramide desaturase 1 (DES1) resolves insulin resistance and fatty liver in mice.

  • The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

    An integrated analysis reveals the changes, down to the molecular level, in one man during a year-long spaceflight.

  • Structural basis of α-scorpion toxin action on Nav channels

    Structures reveal how activation of voltage-gated sodium channels causes conformational changes in a voltage-sensor domain, leading to fast inactivation.

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