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Physiology
- The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3
Intestinal microbiota induces daily metabolic rhythms and controls lipid uptake epigenetically by regulating histone deacetylase 3 cycling.
- Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
Deletion of dihydroceramide desaturase 1 (DES1) resolves insulin resistance and fatty liver in mice.
- Lowering ceramides to overcome diabetes
Lowering toxic lipid concentrations in mice has a promising impact on obesity-associated metabolic disorder
- Fat cell progenitors get singled out
Distinct adipocyte progenitor cells may reveal therapeutic strategies for obesity
- The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
An integrated analysis reveals the changes, down to the molecular level, in one man during a year-long spaceflight.
- Hazards of human spaceflight
A 1-year mission in space has many biological consequences
- Structural basis of α-scorpion toxin action on Nav channels
Structures reveal how activation of voltage-gated sodium channels causes conformational changes in a voltage-sensor domain, leading to fast inactivation.
