Technical Papers

Effect of Some Sulfhydryl-containing Substances on the Toxicity of an Organic Mercurial Compound

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Science  06 Sep 1946:
Vol. 104, Issue 2697, pp. 220-221
DOI: 10.1126/science.104.2697.220


The acute toxicity of an organic mercurial as studied on the mouse, intact anesthetized cat and dog, and the heart-lung preparation of the dog can be readily counteracted by sulfhydryl-containing compounds such as glutathione, cysteine, and 2,3-dimercapto-propanol. Equimolar doses of 2,3-dimercapto-propanol are about five times as active as cysteine or glutathione.