Effect of Reserpine Pretreatment on Stimulation of the Accelerans Nerve of the Dog

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Science  17 Oct 1958:
Vol. 128, Issue 3329, pp. 901-903
DOI: 10.1126/science.128.3329.901-a


Pretreatment with two doses of reserpine (each 0.1 mg/kg, intraperitoneally) sensitizes the heart to the positive chronotropic action of norepinephrine and reduces the response to stimulation of the accelerans nerve. Ganglionic transmission remains unaffected. The results indicate that the presence of certain stores of peripheral sympathetic transmitter is essential for the production of tachycardia by stimulation of the accelerans nerve.