Effect of Oxidation and Reduction upon the Biological Activity of Parathyroid Hormone

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Science  28 Nov 1958:
Vol. 128, Issue 3335, pp. 1347-1348
DOI: 10.1126/science.128.3335.1347


Parathyroid hormone loses biological activity upon oxidation with hydrogen peroxide. Part or all of this lost activity can be regained by subsequent reduction with cysteine. The extent and reversibility of this oxidation is dependent upon pH.