New Type Sedative and Soporific Drug

See allHide authors and affiliations

Science  19 Dec 1958:
Vol. 128, Issue 3338, pp. 1570-1571
DOI: 10.1126/science.128.3338.1570


Trimethoxybenzoyl-glycine-diethylamide induced in dogs and cats normal sleep without preceding ataxia. A five- to ten-fold increase of the soporific dose resulted in restlessness and disorientation instead of sleep. In man, oral doses of 500 to 1500 mg caused sedation or drowsiness, or both, in half the cases. No spindling or drug-induced artifacts were found in electroencephalographic recordings.