Release of Autonomic Mediators in Cardiac Tissue by Suprathreshold Stimulation

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Science  06 Feb 1959:
Vol. 129, Issue 3345, pp. 328-329
DOI: 10.1126/science.129.3345.328


Pharmacological evidence is presented supporting the theory that the increase in contractile strength of isolated cardiac muscle under suprathreshold stimulation is due to the release of an adrenergic mediator (norepinephrine). However, release of this material does not account for changes in contractile strength associated with changes in frequency of stimulation at threshold levels.

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