A Substance in Liver Which Inhibits Thymine Biosynthesis by Bone Marrow

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Science  06 Feb 1959:
Vol. 129, Issue 3345, pp. 336
DOI: 10.1126/science.129.3345.336


A substance was extracted from rabbit liver which inhibited the incorporation of formate into bone-marrow thymine in vitro. In view of the important role of thymine biosynthesis in cell division, it is suggested that the inhibitor present in liver is a naturally occurring mitosis inhibitor.

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