New Method for the Rapid Determination of Lathyrogenic Agents

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Science  13 Mar 1959:
Vol. 129, Issue 3350, pp. 720
DOI: 10.1126/science.129.3350.720


Salamander and toad embryos will develop grossly observable tumors of the notochord if they are placed for 3 or more days in a solution of the lathyrism-producing chemicals beta-aminopropionitrile or aminoacetonitrile. A technique for using tumorigenesis in amphibian embryos as a biological indicator for other lathyrogenic agents is presented.