The Error Hypothesis of Mutation

See allHide authors and affiliations

Science  11 Mar 1960:
Vol. 131, Issue 3402, pp. 730
DOI: 10.1126/science.131.3402.730


Accumulation of mutants in glucose-limited chemostats is proportional to growth rate, while in tryptophan-limited chemostats it is independent of growth rate. This behavior, which implies the failure of the error hypothesis, may be explainable on the basis of a unitary hypothesis: the results with glucose may be due to reversion or loss of latent mutants.

Stay Connected to Science