Increased Incidence of Nontasters of Phenylthiocarbamide among Congenital Athyreotic Cretins

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Science  25 Mar 1960:
Vol. 131, Issue 3404, pp. 929
DOI: 10.1126/science.131.3404.929


The incidence of nontasters for phenylthiocarbamide was found to be significantly higher in 27 athyreotic cretins than in normal adults and children. A significant increase of nontasters among the parents and siblings of these cretins was also found. These findings are discussed in relation to maldevelopment of the fetal thyroid in nontaster genotypes.