Succinylcholine and Muscle Excitability

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Science  03 Jun 1960:
Vol. 131, Issue 3414, pp. 1679-1680
DOI: 10.1126/science.131.3414.1679


Succinylcholine lowers the resting membrane potential taken with microelectrodes similarly in nerve-scarce and innervated portions of frog sartorius muscle. Twitches to electrical excitation of the nerve-scarce pelvic end of the muscle are also rapidly reduced. The results indicate that succinylcholine probably acts generally on the muscle membrance to diminish excitability.