Rapid and Reversible Block of Electrical Activity by Powerful Marine Biotoxins

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Science  29 Jul 1960:
Vol. 132, Issue 3422, pp. 300-301
DOI: 10.1126/science.132.3422.300-a


Puffer-fish poison and clam poison reversibly inhibit conduction in single nerve fiber preparation of frog in a concentration of 3 x 10-10M. In the isolated electroplax of Electrophorus electricus higher concentrations block both transmission and conduction. Neither toxin is a potent acetylcholinesterase inhibitor. The mechanism of action of these toxins in blocking transmission and conduction has not yet been established.