Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds

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Science  04 Aug 1961:
Vol. 134, Issue 3475, pp. 343
DOI: 10.1126/science.134.3475.343


An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine , mescaline, and dopamine.