Hypothalamic Control of Feeding and Self-Stimulation

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Science  02 Feb 1962:
Vol. 135, Issue 3501, pp. 375-377
DOI: 10.1126/science.135.3501.375


Hypothalamic sites which control feeding exert a corresponding control over lateral hypothalamic self-stimulation. This was demonstrated in rats bearing four, intrahypothalamic electrode-cannulas for electrical stimulation or chemical injection. Self-stimulation of the lateral hypothalamus was inhibited by ventromedial excitation or by excessive feeding. Both self-stimulation and feeding were accelerated (disinhibited) by ventromedial ablation or anesthetization. Thus food acts via the ventromedial hypothalamus to inhibit not only feeding, but also lateral hypothalamic self-stimulation.

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