Plasma-Free Corticosteroid Response to Electric Shock in Rats Stimulated in Infancy

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Science  09 Mar 1962:
Vol. 135, Issue 3506, pp. 795-796
DOI: 10.1126/science.135.3506.795-a


Circulating corticosteroids were measured after a brief electric shock in rats which were manipulated during infancy. When compared to nonmanipulated controls it was found that the manipulated rats showed a significant elevation of corticosteroids as early as 15 seconds after shock, whereas the nonmanipulated subjects did not show a significant elevation of steroids until 5 minutes after a brief shock. Further, the levels of corticosteroids were consistently higher in the manipulated subjects over a 15-minute period.